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KMID : 0043319900130010051
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Archives of Pharmacal Research
1990 Volume.13 No. 1 p.51 ~ p.54
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Effect of Scoparone on the Hepatic Sulfotransferase Activity in Mice
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Huh K
Park JM/Shin US/Lee SI
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Abstract
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Effect of scoparone (6,7-dimethoxycoumarin) on the hepatic cytosolic sulfotransferase activity was investigated. After treatment with scoparone, hepatic cytosolic sulfotransferase activity was increased with dose and time-dependent manner as compared to control. The Vmax value (control=1.33nmoles/mg protein/min, scoparone=2.39nmoles/mg protein/min) without affecting the Km value for p-nitrophenol was increased by the scoparone treatment. Whereas, the hepatic cytosolic sulfotransferase was not changed by the addition of scoparone in vitro, and was strongly inhibited by the addition of metabolites of scoparone. The results obtained suggest that the characteristics of increase in the enzyme activity may include induction of enzyme proteins, and may be due to the metabolites of scoparone.
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KEYWORD
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